Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses-Reference-Cited by-同舟云学术

Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses

Published:2020-08-14 Issue:50 Volume:5 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Boland Brigid S.¹^ORCID,He Zhaoren²³^ORCID,Tsai Matthew S.¹^ORCID,Olvera Jocelyn G.¹^ORCID,Omilusik Kyla D.³^ORCID,Duong Han G.¹,Kim Eleanor S.¹^ORCID,Limary Abigail E.¹,Jin Wenhao²^ORCID,Milner J. Justin³^ORCID,Yu Bingfei³,Patel Shefali A.¹,Louis Tiani L.¹^ORCID,Tysl Tiffani¹^ORCID,Kurd Nadia S.¹^ORCID,Bortnick Alexandra³^ORCID,Quezada Lauren K.¹^ORCID,Kanbar Jad N.¹,Miralles Ara¹^ORCID,Huylebroeck Danny⁴⁵^ORCID,Valasek Mark A.⁶,Dulai Parambir S.¹,Singh Siddharth¹,Lu Li-Fan³^ORCID,Bui Jack D.⁶^ORCID,Murre Cornelis³^ORCID,Sandborn William J.¹,Goldrath Ananda W.³,Yeo Gene W.²⁷,Chang John T.¹⁸^ORCID

Affiliation:

1. Department of Medicine, University of California, San Diego, La Jolla, CA, USA.

2. Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.

3. Division of Biologic Sciences, University of California, San Diego, La Jolla, CA, USA.

4. Department of Development and Regeneration, University of Leuven, Leuven, Belgium.

5. Department of Cell Biology, Erasmus University Medical Center Rotterdam, 3015 CN Rotterdam, Netherlands.

6. Department of Pathology, University of California, San Diego, La Jolla, CA, USA.

7. Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA.

8. Division of Gastroenterology, VA San Diego Healthcare System, San Diego, CA, USA.

Abstract

Single-cell sequencing analyses reveal changes in B and T cell transcriptional states in the context of ulcerative colitis.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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