Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice-Reference-Cited by-同舟云学术

Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice

Published:2020-07-13 Issue:8 Volume:26 Page:1264-1270
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Suriben Rowena^ORCID,Chen Michael,Higbee Jared^ORCID,Oeffinger Julie,Ventura Richard^ORCID,Li Betty,Mondal Kalyani,Gao Zhengyu,Ayupova Dina,Taskar Pranali^ORCID,Li Diana^ORCID,Starck Shelley R.,Chen Hung-I Harry,McEntee Michele,Katewa Subhash D.,Phung Van,Wang Marilyn^ORCID,Kekatpure Avantika,Lakshminarasimhan Damodharan,White Andre^ORCID,Olland Andrea,Haldankar Raj,Solloway Mark J.,Hsu Jer-Yuan,Wang Yan,Tang Jie,Lindhout Darrin A.,Allan Bernard B.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/s41591-020-0945-x.pdf

Reference32 articles.

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2. Baracos, V. E., Martin, L., Korc, M., Guttridge, D. C. & Fearon, K. C. H. Cancer-associated cachexia. Nat. Rev. Dis. Prim. 4, 17105 (2018).

3. Burfeind, K. G., Michaelis, K. A. & Marks, D. L. The central role of hypothalamic inflammation in the acute illness response and cachexia. Semin Cell Dev. Biol. 54, 42–52 (2016).

4. Argiles, J. M., Busquets, S., Stemmier, B. & Lopez-Soriano, F. J. Cancer cachexia: understanding the molecular basis. Nat. Rev. Cancer 14, 754–762 (2014).

5. Johnen, H. et al. Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1. Nat. Med. 13, 1333–1340 (2007).

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