Low-dose orthotopic cancer implantation permits measurement of longitudinal functional changes associated with cachexia-Reference-Cited by-同舟云学术

Low-dose orthotopic cancer implantation permits measurement of longitudinal functional changes associated with cachexia

Published:2024-09-01 Issue:3 Volume:137 Page:705-717
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Roy Ishan¹²³^ORCID,Binder-Markey Benjamin⁴^ORCID,Willbanks Amber¹,Sychowski Danielle¹,Phipps Tenisha¹,Barber Addison¹,McAllister Donna⁵,D’Andrea Dominic¹,Franz Colin K.¹²^ORCID,Pichika Rajeswari¹²⁶,Dwinell Michael B.⁵^ORCID,Lieber Richard L.¹²⁶^ORCID

Affiliation:

1. Shirley Ryan AbilityLab, Chicago, Illinois, United States

2. Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, Illinois, United States

3. Robert H. Lurie Cancer Center of Northwestern University, Chicago, Illinois, United States

4. Department of Physical Therapy and Rehabilitation Sciences, Drexel, University, Philadelphia, Pennsylvania, United States

5. Department of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States

6. Hines VA Medical Center, Maywood, Illinois, United States

Abstract

Previous studies of cancer-induced cachexia have been confounded by the relatively rapid death of animal subjects. Using a lower dose of cancer cells in combination with a battery of behavioral, structural, histological, and biochemical techniques, we show that gait speed is actually the best indicator of functional decline due to cachexia. Future studies are required to define the underlying physiological basis of these findings.

Funder

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00173.2024

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