The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity
Author:
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Structural Biology
Link
http://www.nature.com/articles/nsmb.1738.pdf
Reference37 articles.
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2. Henderson, L.M., Chappell, J.B. & Jones, O.T. The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel. Biochem. J. 246, 325–329 (1987).
3. DeCoursey, T.E., Morgan, D. & Cherny, V.V. The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels. Nature 422, 531–534 (2003).
4. Ramsey, I.S., Ruchti, E., Kaczmarek, J.S. & Clapham, D.E. Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proc. Natl. Acad. Sci. USA 106, 7642–7647 (2009).
5. Ramsey, I.S., Moran, M.M., Chong, J.A. & Clapham, D.E. A voltage-gated proton-selective channel lacking the pore domain. Nature 440, 1213–1216 (2006).
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