An interaction quantitative trait loci tool implicates epistatic functional variants in an apoptosis pathway in smallpox vaccine eQTL data
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Immunology
Link
http://www.nature.com/articles/gene201615.pdf
Reference42 articles.
1. Fehrmann RS, Jansen RC, Veldink JH, Westra HJ, Arends D, Bonder MJ et al. Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. PLoS Genet 2011; 7: e1002197.
2. Becker J, Wendland JR, Haenisch B, Nothen MM, Schumacher J . A systematic eQTL study of cis-trans epistasis in 210 HapMap individuals. Eur J Hum Genet 2012; 20: 97–101.
3. Kapur K, Schupbach T, Xenarios I, Kutalik Z, Bergmann S . Comparison of strategies to detect epistasis from eQTL data. PLoS One 2011; 6: e28415.
4. Cordell HJ . Epistasis: what it means, what it doesn’t mean, and statistical methods to detect it in humans. Hum Mol Genet 2002; 11: 2463–2468.
5. Phillips PC . Epistasis—the essential role of gene interactions in the structure and evolution of genetic systems. Nat Rev Genet 2008; 9: 855–867.
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