Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila-Reference-Cited by-同舟云学术

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Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila

Published:1999-11 Issue:3 Volume:23 Page:363-366
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Lyko Frank,Ramsahoye Bernard H.,Kashevsky Helena,Tudor Matthew,Mastrangelo Mary-Ann,Orr-Weaver Terry L.,Jaenisch Rudolf

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

http://www.nature.com/articles/ng1199_363.pdf

Reference31 articles.

1. Li, E., Bestor, T.H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915–926 (1992).

2. Li, E., Beard, C. & Jaenisch, R. Role for DNA methylation in genomic imprinting. Nature 366, 362–365 ( 1993).

3. Panning, B. & Jaenisch, R. DNA hypomethylation can activate Xist expression and silence X-linked genes. Genes Dev. 10, 1991–2002 (1996).

4. Chen, R.Z., Pettersson, U., Beard, C., Jackson-Grusby, L. & Jaenisch, R. DNA hypomethylation leads to elevated mutation rates. Nature 395, 89– 93 (1998).

5. Walsh, C.P., Chaillet, J.R. & Bestor, T.H. Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Nature Genet. 20, 116–117 (1998).

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