A General Network Pharmacodynamic Model-Based Design Pipeline for Customized Cancer Therapy Applied to the VEGFR Pathway-Reference-Cited by-同舟云学术

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A General Network Pharmacodynamic Model-Based Design Pipeline for Customized Cancer Therapy Applied to the VEGFR Pathway

Published:2014-01 Issue:1 Volume:3 Page:92
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT: Pharmacometrics & Systems Pharmacology

Author:

Zhang X-Y¹,Birtwistle MR¹,Gallo JM¹

Affiliation:

1. Department of Pharmacology and Systems Therapeutics; Icahn School of Medicine at Mount Sinai; New York New York USA

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1038/psp.2013.65/fullpdf

Reference49 articles.

1. Computation as the mechanistic bridge between precision medicine and systems therapeutics;Hansen;Clin. Pharmacol. Ther.,2013

2. Merging systems biology with pharmacodynamics;Iyengar;Sci. Transl. Med.,2012

3. Development of translational pharmacokinetic-pharmacodynamic models;Mager;Clin. Pharmacol. Ther.,2008

4. Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy;Hector;Gut,2012

5. Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells;Panetta;PLoS Comput. Biol.,2010

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