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Merging Systems Biology with Pharmacodynamics

Published:2012-03-21 Issue:126 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Iyengar Ravi¹,Zhao Shan¹,Chung Seung-Wook¹,Mager Donald E.²,Gallo James M.¹

Affiliation:

1. Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA

2. Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.

Abstract

Enhanced pharmacodynamic models combine favorable features of systems biology and traditional models and may form the basis of precision medicine.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference31 articles.

1. Genetic and clinical factors relating to warfarin dosing

2. Toward Predictive Models of Mammalian Cells

3. Emergent Properties of Networks of Biological Signaling Pathways

4. MAP Kinase Phosphatase As a Locus of Flexibility in a Mitogen-Activated Protein Kinase Signaling Network

5. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

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