TGF-β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN-Reference-Cited by-同舟云学术

TGF-β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN

Published:2009-06-21 Issue:7 Volume:11 Page:881-889
ISSN:1465-7392
Container-title:Nature Cell Biology
language:en
Short-container-title:Nat Cell Biol

Author:

Kato Mitsuo,Putta Sumanth,Wang Mei,Yuan Hang,Lanting Linda,Nair Indu,Gunn Amanda,Nakagawa Yoshimi,Shimano Hitoshi,Todorov Ivan,Rossi John J.,Natarajan Rama

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology

Link

http://www.nature.com/articles/ncb1897.pdf

Reference34 articles.

1. Yamamoto, T., Nakamura, T., Noble, N. A., Ruoslahti, E. & Border, W. A. Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy. Proc. Natl Acad. Sci. USA 90, 1814–1818 (1993).

2. Sharma, K. & Ziyadeh, F. N. Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-β as a key mediator. Diabetes 44, 1139–1146 (1995).

3. Kato, M. et al. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc. Natl Acad. Sci. USA 104, 3432–3437 (2007).

4. Kato, M. et al. Role of the Akt/FoxO3a pathway in TGF-β1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease. J. Am. Soc. Nephrol 17, 3325–3335 (2006).

5. Mahimainathan, L., Das, F., Venkatesan, B. & Choudhury, G. G. Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN. Diabetes 55, 2115–2125 (2006).

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