Tissue Oxygen Saturation Mapping with Magnetic Resonance Imaging

Author:

Christen Thomas123,Bouzat Pierre1243,Pannetier Nicolas12,Coquery Nicolas12,Moisan Anaïck12,Lemasson Benjamin12,Thomas Sébastien124,Grillon Emmanuelle5678,Detante Olivier129,Rémy Chantal12,Payen Jean-François124,Barbier Emmanuel Luc12

Affiliation:

1. Inserm, U836, Grenoble, France

2. Université Grenoble Alpes, Grenoble Institut des Neurosciences, Grenoble, France

3. These are co-first authors

4. CHU Grenoble, Pôle d'Anesthésie-Réanimation, Grenoble, France

5. Inserm, US 017, Grenoble, France

6. Université Grenoble Alpes, IRMaGe, Grenoble, France

7. CHU Grenoble, IRMaGe, Grenoble, France

8. CNRS, UMS 3552, Grenoble, France

9. CHU Grenoble, Service de Neurologie, Grenoble, France

Abstract

A quantitative estimate of cerebral blood oxygen saturation is of critical importance in the investigation of cerebrovascular disease. While positron emission tomography can map in vivo the oxygen level in blood, it has limited availability and requires ionizing radiation. Magnetic resonance imaging (MRI) offers an alternative through the blood oxygen level-dependent contrast. Here, we describe an in vivo and non-invasive approach to map brain tissue oxygen saturation ( StO2) with high spatial resolution. StO2 obtained with MRI correlated well with results from blood gas analyses for various oxygen and hematocrit challenges. In a stroke model, the hypoxic areas delineated in vivo by MRI spatially matched those observed ex vivo by pimonidazole staining. In a model of diffuse traumatic brain injury, MRI was able to detect even a reduction in StO2 that was too small to be detected by histology. In a F98 glioma model, MRI was able to map oxygenation heterogeneity. Thus, the MRI technique may improve our understanding of the pathophysiology of several brain diseases involving impaired oxygenation.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

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