Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding

Author:

Yen Chi-Liang Eric,Cheong Mei-Leng,Grueter Carrie,Zhou Ping,Moriwaki Junya,Wong Jinny S,Hubbard Brian,Marmor Stephen,Farese Robert V

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference23 articles.

1. Neel, J.V. Diabetes mellitus: a 'thrifty' genotype rendered detrimental by 'progress'? Am. J. Hum. Genet. 14, 353–362 (1962).

2. Muoio, D.M. & Newgard, C.B. Obesity-related derangements in metabolic regulation. Annu. Rev. Biochem. 75, 367–401 (2006).

3. The Food and Agricultural Organization of the United Nations. Food Consumption: Dietary Energy, Protein and Fat. http://www.fao.org/ faostat/foodsecurity/index_en.htm (2008).

4. Bell, R.M. & Coleman, R.A. Enzymes of glycerolipid synthesis in eukaryotes. Annu. Rev. Biochem. 49, 459–487 (1980).

5. Senior, J.R. & Isselbacher, K.J. Direct esterification of monoglycerides with palmityl coenzyme A by intestinal epithelial subcellular fractions. J. Biol. Chem. 237, 1454–1459 (1962).

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