CART peptides: regulators of body weight, reward and other functions
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Link
http://www.nature.com/articles/nrn2493.pdf
Reference171 articles.
1. Douglass, J., McKinzie, A. A. & Couceyro, P. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J. Neurosci. 15, 2471–2481 (1995). This basic paper established the field of CART peptide research. It also demonstrated the psychostimulant effect which, although sometimes controversial, has been confirmed several times, as summarized in reference 100.
2. Spiess, J., Villarreal, J. & Vale, W. Isolation and sequence analysis of a somatostatin-like polypeptide from ovine hypothalamus. Biochemistry 20, 1982–1988 (1981).
3. Thim, L., Kristensen, P., Nielsen, P. F., Wulff, B. S. & Clausen, J. T. Tissue-specific processing of cocaine- and amphetamine-regulated transcript peptides in the rat. Proc. Natl Acad. Sci. USA 96, 2722–2727 (1999). This study elucidated the tissue-specific processing and sequence of specific CART peptides. Reference 8 was a strong follow-up to this work.
4. Dominguez, G. The CART gene: structure and regulation. Peptides 27, 1913–1918 (2006).
5. Thim, L. et al. Purification and characterisation of a new hypothalamic satiety peptide, cocaine and amphetamine regulated transcript (CART), produced in yeast. FEBS Lett. 428, 263–268 (1998).
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