Lifestyle Risk Score: handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions

Author:

Xu HanfeiORCID,Schwander Karen,Brown Michael R.,Wang Wenyi,Waken R. J.,Boerwinkle Eric,Cupples L. AdrienneORCID,de las Fuentes LisaORCID,van Heemst Diana,Osazuwa-Peters Oyomoare,de Vries Paul S.,van Dijk Ko Willems,Sung Yun Ju,Zhang Xiaoyu,Morrison Alanna C.,Rao D. C.,Noordam RaymondORCID,Liu Ching-TiORCID

Funder

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Genetics

Reference41 articles.

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2. López-Cortegano E, Caballero A. Inferring the nature of missing heritability in human traits using data from the GWAS catalog. Genetics 2019;212:891–904.

3. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, et al. Finding the missing heritability of complex diseases. Nat Nat Publ Group. 2009;461:747–53.

4. Rao DC, Sung YJ, Winkler TW, Schwander K, Borecki I, Adrienne Cupples L, et al. Multiancestry study of gene-lifestyle interactions for cardiovascular traits in 610 475 individuals from 124 cohorts: design and rationale. Circ Cardiovasc Genet. 2017;10:e001649.

5. Noordam R, Bos MM, Wang H, Winkler TW, Bentley AR, Kilpeläinen TO, et al. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Nat Commun. 2019;10:5121.

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