Neuroprotective mechanisms of hypothermia in brain ischaemia
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Link
http://www.nature.com/articles/nrn3174.pdf
Reference126 articles.
1. Busto, R. et al. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J. Cereb. Blood Flow Metab. 7, 729–738 (1987). This study was the first to show that relatively small decreases in temperature resulted in remarkable neuroprotection and led to a resurgence of interest in the field of therapeutic hypothermia.
2. Bernard, S. A. et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N. Engl. J. Med. 346, 557–563 (2002).
3. The Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N. Engl. J. Med. 346, 549–556 (2002). References 2 and 3 are prospective clinical studies that showed that mild hypothermia improved neurological outcomes in victims of cardiac arrest.
4. Gluckman, P. D. et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 365, 663–670 (2005). Aclinical trial of selective head cooling that showed improvement in neurological outcomes in some neonates with hypoxic ischaemic encephalopathy.
5. Shankaran, S. et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N. Engl. J. Med. 353, 1574–1584 (2005). A clinical trial of whole body cooling that showed improvement in neurological outcomes in some neonates with hypoxic ischaemic encephalopathy.
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