Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC

Author:

Morak Monika,Schackert Hans Konrad,Rahner Nils,Betz Beate,Ebert Matthias,Walldorf Constanze,Royer-Pokora Brigitte,Schulmann Karsten,von Knebel-Doeberitz Magnus,Dietmaier Wolfgang,Keller Gisela,Kerker Brigitte,Leitner Gertraud,Holinski-Feder Elke

Publisher

Springer Science and Business Media LLC

Subject

Genetics(clinical),Genetics

Reference51 articles.

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2. Vasen HF, Mecklin JP, Khan PM, Lynch HT : The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum 1991; 34: 424–425.

3. Vasen HF, Watson P, Mecklin JP, Lynch HT : New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC. Gastroenterology 1999; 116: 1453–1456.

4. Boland CR, Thibodeau SN, Hamilton SR et al: A National Cancer Institute Workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998; 58: 5248–5257.

5. Deng G, Chen A, Hong J, Chae HS, Kim YS : Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression. Cancer Res 1999; 59: 2029–2033.

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