CRISPR/Cas9 can mediate high-efficiency off-target mutations in mice in vivo
Author:
Funder
UT | University of Texas MD Anderson Cancer Center
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology
Link
http://www.nature.com/articles/s41419-018-1146-0.pdf
Reference11 articles.
1. Ma, H. et al. Correction of a pathogenic gene mutation in human embryos. Nature, 548, 413–419 (2017).
2. Tang, L. et al. CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein. Mol. Genet. Genom. 292, 525–533 (2017).
3. Hsu, P. D. et al. DNA targeting specificity of RNA-guided Cas9 nucleases. Nat. Biotechnol. 31, 827–832 (2013).
4. Fu, Y. et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat. Biotechnol. 31, 822–826 (2013).
5. Iyer, V. et al. Off-target mutations are rare in Cas9-modified mice. Nat. Methods 12, 479 (2015).
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