Genome-wide genetic mutations accumulated in genome-edited pigs and their filial generation for xenotransplantation
Author:
Affiliation:
1. Capital Medical University
2. University of Chinese Academy of Sciences
3. Chengdu Clonorgan Biotechnology Co., LTD
4. Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
5. Institute of Biophysics, CAS
Abstract
Publisher
Research Square Platform LLC
Reference91 articles.
1. Xenotransplantation in China: Present status;Wang Y;Xenotransplantation,2019
2. Genetic engineering of pigs for xenotransplantation to overcome immune rejection and physiological incompatibilities: The first clinical steps;Lei T;Front Immunol,2022
3. Sachs, D.H. The pig as a potential xenograft donor. Vet Immunol Immunopathol 43, 185 – 91 (1994).
4. CRISPR/Cas9-Mediated Gene Editing in Porcine Models for Medical Research;Gao M;DNA Cell Biol,2021
5. Transplanting organs from pigs to humans;Sykes M;Sci Immunol,2019
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