The immunology of susceptibility and resistance to Leishmania major in mice

Author:

Sacks David,Noben-Trauth Nancy

Publisher

Springer Science and Business Media LLC

Subject

Energy Engineering and Power Technology,Fuel Technology

Reference140 articles.

1. Sadick, M. D. et al. Cure of murine leishmaniasis with anti-interleukin-4 monoclonal antibody. Evidence for a T-cell-dependent, interferon-γ-independent mechanism. J. Exp. Med. 171, 115–127 (1990).

2. Chatelain, R., Varkila, K. & Coffman, R. L. IL-4 induces a TH2 response in Leishmania major-infected mice. J. Immunol. 148, 1182–1187 (1992).

3. Kopf, M. et al. IL-4-deficient BALB/c mice resist infection with Leishmania major. J. Exp. Med. 184, 1127–1136 (1996).

4. Mohrs, M. et al. Differences between IL-4- and IL-4 receptor α-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling. J. Immunol. 162, 7302–7308 (1999).References 1–4 provide strong evidence that the production of IL-4 is essential for susceptibility to Leishmania major.

5. Launois, P. et al. IL-4 rapidly produced by Vβ4 Vα8 CD4+ T cells instructs TH2 development and susceptibility to Leishmania major in BALB/c mice. Immunity 6, 541–549 (1997).

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