Aptamers as targeted therapeutics: current potential and challenges
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd.2016.199.pdf
Reference250 articles.
1. Tuerk, C. & Gold, L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249, 505–510 (1990). One of the first three publications of the SELEX technology. A related smaller randomized library theoretically containing 48 individual sequences was used for the selection of RNA ligands for T4 DNA polymerase. This procedure was thus named 'systematic evolution of ligands by exponential enrichment' (SELEX).
2. Robertson, D. L. & Joyce, G. F. Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA. Nature 344, 467–468 (1990). One of the first three publications of the SELEX technology. The first RNA enzyme that could cleave ssDNA specifically was selected via in vitro selection.
3. Ellington, A. D. & Szostak, J. W. In vitro selection of RNA molecules that bind specific ligands. Nature 346, 818–822 (1990). One of the first three publications of the SELEX technology. The first example of an RNA aptamer specific to small organic dyes.
4. Mayer, G. The chemical biology of aptamers. Angew. Chem. Int. Ed. 48, 2672–2689 (2009).
5. Gelinas, A. D., Davies, D. R. & Janjic, N. Embracing proteins: structural themes in aptamer–protein complexes. Curr. Opin. Struct. Biol. 36, 122–132 (2016).
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