Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1-Reference-Cited by-同舟云学术

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Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1

Published:2011-07 Issue:7 Volume:2 Page:e182-e182
ISSN:2041-4889
Container-title:Cell Death & Disease
language:en
Short-container-title:Cell Death Dis

Author:

Polier G,Ding J,Konkimalla B V,Eick D,Ribeiro N,Köhler R,Giaisi M,Efferth T,Desaubry L,Krammer P H,Li-Weber M

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology

Link

http://www.nature.com/articles/cddis201166.pdf

Reference40 articles.

1. Li-Weber M . New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents wogonin, baicalein and baicalin. Cancer Treat Rev 2009; 35: 57–68.

2. Wang W, Guo QL, You QD, Zhang K, Yang Y, Yu J et al. The anticancer activities of wogonin in murine sarcoma S180 both in vitro and in vivo. Biol Pharm Bull 2006; 29: 1132–1137.

3. Baumann S, Fas SC, Giaisi M, Muller WW, Merling A, Gulow K et al. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. Blood 2008; 111: 2354–2363.

4. Chung H, Jung YM, Shin DH, Lee JY, Oh MY, Kim HJ et al. Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts. Int J Cancer 2008; 122: 816–822.

5. Lu N, Gao Y, Ling Y, Chen Y, Yang Y, Gu HY et al. Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. Life Sci 2008; 82: 956–963.

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