Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2

Author:

Lu Na,Gao Ying,Ling Yun,Chen Yan,Yang Yong,Gu Hong-Yan,Qi Qi,Liu Wei,Wang Xiao-Tang,You Qi-Dong,Guo Qing-Long

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference49 articles.

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2. Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent;Bernatchez;Journal of Biological Chemistry,1999

3. Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis;Binetruy-Tournaire;EMBO Journal,2000

4. Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1;Chen;Archives of Toxicology,2002

5. Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells;Chi;Biochemical Pharmacology,2001

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