Author:
Fu Xianglei,Shi Yanbin,Qi Tongtong,Qiu Shengnan,Huang Yi,Zhao Xiaogang,Sun Qifeng,Lin Guimei
Abstract
Abstract
Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final targets. The optimal targets of most cancer therapeutic agents are usually biological macromolecules at the subcellular level, which play a key role in carcinogenesis. Therefore, to improve the therapeutic efficiency of drugs, researchers need to focus on delivering not only the therapeutic agents to the target tissues and cells but also the drugs to the relevant subcellular structures. In this review, we discuss the most recent construction strategies and release patterns of various cancer cell subcellular-targeting nanoformulations, aiming at providing guidance in the overall design of precise nanomedicine. Additionally, future challenges and potential perspectives are illustrated in the hope of enhancing anticancer efficacy and accelerating the translational progress of precise nanomedicine.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Shandong Province
the Fundamental Research Funds of Shandong University
the Major Basic Research Project of Shandong Natural Science Foundation, P. R. China
Publisher
Springer Science and Business Media LLC
Cited by
71 articles.
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