The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

Author:

Rozenblatt-Rosen Orit,Regev Aviv,Oberdoerffer Philipp,Nawy Tal,Hupalowska Anna,Rood Jennifer E.,Ashenberg Orr,Cerami Ethan,Coffey Robert J.,Demir Emek,Ding Li,Esplin Edward D.,Ford James M.,Goecks Jeremy,Ghosh Sharmistha,Gray Joe W.,Guinney Justin,Hanlon Sean E.,Hughes Shannon K.,Hwang E. Shelley,Iacobuzio-Donahue Christine A.,Jané-Valbuena Judit,Johnson Bruce E.,Lau Ken S.,Lively Tracy,Mazzilli Sarah A.,Pe’er Dana,Santagata Sandro,Shalek Alex K.,Schapiro Denis,Snyder Michael P.,Sorger Peter K.,Spira Avrum E.,Srivastava Sudhir,Tan Kai,West Robert B.,Williams Elizabeth H.,Aberle Denise,Achilefu Samuel I.,Ademuyiwa Foluso O.,Adey Andrew C.,Aft Rebecca L.,Agarwal Rachana,Aguilar Ruben A.,Alikarami Fatemeh,Allaj Viola,Amos Christopher,Anders Robert A.,Angelo Michael R.,Anton Kristen,Ashenberg Orr,Aster Jon C.,Babur Ozgun,Bahmani Amir,Balsubramani Akshay,Barrett David,Beane Jennifer,Bender Diane E.,Bernt Kathrin,Berry Lynne,Betts Courtney B.,Bletz Julie,Blise Katie,Boire Adrienne,Boland Genevieve,Borowsky Alexander,Bosse Kristopher,Bott Matthew,Boyden Ed,Brooks James,Bueno Raphael,Burlingame Erik A.,Cai Qiuyin,Campbell Joshua,Caravan Wagma,Cerami Ethan,Chaib Hassan,Chan Joseph M.,Chang Young Hwan,Chatterjee Deyali,Chaudhary Ojasvi,Chen Alyce A.,Chen Bob,Chen Changya,Chen Chia-hui,Chen Feng,Chen Yu-An,Chheda Milan G.,Chin Koei,Chiu Roxanne,Chu Shih-Kai,Chuaqui Rodrigo,Chun Jaeyoung,Cisneros Luis,Coffey Robert J.,Colditz Graham A.,Cole Kristina,Collins Natalie,Contrepois Kevin,Coussens Lisa M.,Creason Allison L.,Crichton Daniel,Curtis Christina,Davidsen Tanja,Davies Sherri R.,de Bruijn Ino,Dellostritto Laura,De Marzo Angelo,Demir Emek,DeNardo David G.,Diep Dinh,Ding Li,Diskin Sharon,Doan Xengie,Drewes Julia,Dubinett Stephen,Dyer Michael,Egger Jacklynn,Eng Jennifer,Engelhardt Barbara,Erwin Graham,Esplin Edward D.,Esserman Laura,Felmeister Alex,Feiler Heidi S.,Fields Ryan C.,Fisher Stephen,Flaherty Keith,Flournoy Jennifer,Ford James M.,Fortunato Angelo,Frangieh Allison,Frye Jennifer L.,Fulton Robert S.,Galipeau Danielle,Gan Siting,Gao Jianjiong,Gao Long,Gao Peng,Gao Vianne R.,Geiger Tim,George Ajit,Getz Gad,Ghosh Sharmistha,Giannakis Marios,Gibbs David L.,Gillanders William E.,Goecks Jeremy,Goedegebuure Simon P.,Gould Alanna,Gowers Kate,Gray Joe W.,Greenleaf William,Gresham Jeremy,Guerriero Jennifer L.,Guha Tuhin K.,Guimaraes Alexander R.,Guinney Justin,Gutman David,Hacohen Nir,Hanlon Sean,Hansen Casey R.,Harismendy Olivier,Harris Kathleen A.,Hata Aaron,Hayashi Akimasa,Heiser Cody,Helvie Karla,Herndon John M.,Hirst Gilliam,Hodi Frank,Hollmann Travis,Horning Aaron,Hsieh James J.,Hughes Shannon,Huh Won Jae,Hunger Stephen,Hwang Shelley E.,Iacobuzio-Donahue Christine A.,Ijaz Heba,Izar Benjamin,Jacobson Connor A.,Janes Samuel,Jané-Valbuena Judit,Jayasinghe Reyka G.,Jiang Lihua,Johnson Brett E.,Johnson Bruce,Ju Tao,Kadara Humam,Kaestner Klaus,Kagan Jacob,Kalinke Lukas,Keith Robert,Khan Aziz,Kibbe Warren,Kim Albert H.,Kim Erika,Kim Junhyong,Kolodzie Annette,Kopytra Mateusz,Kotler Eran,Krueger Robert,Krysan Kostyantyn,Kundaje Anshul,Ladabaum Uri,Lake Blue B.,Lam Huy,Laquindanum Rozelle,Lau Ken S.,Laughney Ashley M.,Lee Hayan,Lenburg Marc,Leonard Carina,Leshchiner Ignaty,Levy Rochelle,Li Jerry,Lian Christine G.,Lim Kian-Huat,Lin Jia-Ren,Lin Yiyun,Liu Qi,Liu Ruiyang,Lively Tracy,Longabaugh William J.R.,Longacre Teri,Ma Cynthia X.,Macedonia Mary Catherine,Madison Tyler,Maher Christopher A.,Maitra Anirban,Makinen Netta,Makowski Danika,Maley Carlo,Maliga Zoltan,Mallo Diego,Maris John,Markham Nick,Marks Jeffrey,Martinez Daniel,Mashl Robert J.,Masilionais Ignas,Mason Jennifer,Massagué Joan,Massion Pierre,Mattar Marissa,Mazurchuk Richard,Mazutis Linas,Mazzilli Sarah A.,McKinley Eliot T.,McMichael Joshua F.,Merrick Daniel,Meyerson Matthew,Miessner Julia R.,Mills Gordon B.,Mills Meredith,Mondal Suman B.,Mori Motomi,Mori Yuriko,Moses Elizabeth,Mosse Yael,Muhlich Jeremy L.,Murphy George F.,Navin Nicholas E.,Nawy Tal,Nederlof Michel,Ness Reid,Nevins Stephanie,Nikolov Milen,Nirmal Ajit Johnson,Nolan Garry,Novikov Edward,Oberdoerffer Philipp,O’Connell Brendan,Offin Michael,Oh Stephen T.,Olson Anastasiya,Ooms Alex,Ossandon Miguel,Owzar Kouros,Parmar Swapnil,Patel Tasleema,Patti Gary J.,Pe’er Dana,Pe'er Itsik,Peng Tao,Persson Daniel,Petty Marvin,Pfister Hanspeter,Polyak Kornelia,Pourfarhangi Kamyar,Puram Sidharth V.,Qiu Qi,Quintanal-Villalonga Álvaro,Raj Arjun,Ramirez-Solano Marisol,Rashid Rumana,Reeb Ashley N.,Regev Aviv,Reid Mary,Resnick Adam,Reynolds Sheila M.,Riesterer Jessica L.,Rodig Scott,Roland Joseph T.,Rosenfield Sonia,Rotem Asaf,Roy Sudipta,Rozenblatt-Rosen Orit,Rudin Charles M.,Ryser Marc D.,Santagata Sandro,Santi-Vicini Maria,Sato Kazuhito,Schapiro Denis,Schrag Deborah,Schultz Nikolaus,Sears Cynthia L.,Sears Rosalie C.,Sen Subrata,Sen Triparna,Shalek Alex,Sheng Jeff,Sheng Quanhu,Shoghi Kooresh I.,Shrubsole Martha J.,Shyr Yu,Sibley Alexander B.,Siex Kiara,Simmons Alan J.,Singer Dinah S.,Sivagnanam Shamilene,Slyper Michal,Snyder Michael P.,Sokolov Artem,Song Sheng-Kwei,Sorger Peter K.,Southard-Smith Austin,Spira Avrum,Srivastava Sudhir,Stein Janet,Storm Phillip,Stover Elizabeth,Strand Siri H.,Su Timothy,Sudar Damir,Sullivan Ryan,Surrey Lea,Suvà Mario,Tan Kai,Terekhanova Nadezhda V.,Ternes Luke,Thammavong Lisa,Thibault Guillaume,Thomas George V.,Thorsson Vésteinn,Todres Ellen,Tran Linh,Tyler Madison,Uzun Yasin,Vachani Anil,Van Allen Eliezer,Vandekar Simon,Veis Deborah J.,Vigneau Sébastien,Vossough Arastoo,Waanders Angela,Wagle Nikhil,Wang Liang-Bo,Wendl Michael C.,West Robert,Williams Elizabeth H.,Wu Chi-yun,Wu Hao,Wu Hung-Yi,Wyczalkowski Matthew A.,Xie Yubin,Yang Xiaolu,Yapp Clarence,Yu Wenbao,Yuan Yinyin,Zhang Dadong,Zhang Kun,Zhang Mianlei,Zhang Nancy,Zhang Yantian,Zhao Yanyan,Zhou Daniel Cui,Zhou Zilu,Zhu Houxiang,Zhu Qin,Zhu Xiangzhu,Zhu Yuankun,Zhuang Xiaowei

Funder

National Cancer Institute Cancer Moonshot

Janssen Research & Development LLC

Johnson & Johnson

NIH National Cancer Institute

Klarman Cell Observatory at the Broad Institute

Swiss National Science Foundation

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference75 articles.

1. High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin;Achim;Nat. Biotechnol.,2015

2. MAGAN: aligning biological manifolds. arXiv arXiv:1803.00385;Amodio,2018

3. Multiplexed ion beam imaging of human breast tumors;Angelo;Nat. Med.,2014

4. MOFA+: a probabilistic framework for comprehensive integration of structured single-cell data;Argelaguet;bioRxiv,2019

5. Single-cell map of diverse immune phenotypes in the breast tumor microenvironment;Azizi;Cell,2018

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