Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application
Author:
Funder
European Association for Cancer Research
First author of this article
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics
Link
http://www.nature.com/articles/s41392-020-0177-z.pdf
Reference5 articles.
1. Iyer, S., Darley, P. I. & Acharya, K. R. Structural insights into the binding of vascular endothelial growth factor-B by VEGFR-1D2 recognition and specificity. J. Biol. Chem. 285, 23779–23789 (2010).
2. Sadremomtaz, A. et al. Dual blockade of VEGFR1 and VEGFR2 by a novel peptide abrogates VEGF driven angiogenesis, tumor growth, and metastasis through PI3K/ AKT and MAPK/ERK1/2 pathway. Biochim. Biophys. Acta Gen. Subj. 1862, 2688–2700 (2018).
3. Wiesmann, C. et al. Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor. Cell 5, 695–704 (1997).
4. Wang, L. et al. Identification of peptidic antagonists of vascular endothelial growth factor receptor 1 by scanning the binding epitopes of its ligands. J. Med. Chem. 60, 6598–6606 (2017).
5. Sadremomtaz, A. et al. Suppression of migratory and metastatic pathways via blocking VEGFR1 and VEGFR2. J. Recept. Signal Transduct. Res. 38, 432–441 (2018).
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