Affiliation:
1. Department of Hepatobiliary Surgery Hunan Provincial People's Hospital/The First Affiliated Hospital of Hunan Normal University Changsha China
2. Department of Cardiology Xiangdong Hospital Affiliated to Hunan Normal University Liling China
3. Central Laboratory of Hunan Provincial People's Hospital/The First Affiliated Hospital of Hunan Normal University Changsha China
4. Department of Nuclear Medicine Hunan Provincial People's Hospital/The First Affiliated Hospital of Hunan Normal University Changsha China
5. Institute of Emergency Medicine/Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics Hunan Provincial People's Hospital/The First Affiliated Hospital of Hunan Normal University Changsha China
Abstract
AbstractHepatocellular carcinoma (HCC) is the fourth leading cause of cancer‐related deaths among cancer patients. Vascular endothelial growth factor A (VEGFA) is involved in regulating biological processes, such as angiogenesis and vascular permeability, and is very closely related to the pathogenesis of various tumours, especially vascular‐rich, solid tumours. Clinical data of patients with HCC and other tumours were analysed through public databases, such as the TCGA database, Gene Expression Omnibus database, Human Protein Atlas database, STRING, Tumour Immune Estimation Resource and Kaplan–Meier Plotter. The tumour tissues and adjacent normal tissues of patients with HCC from Hunan Provincial People's Hospital were collected to verify the expression of VEGFA by immunohistochemistry, immunofluorescence, Western blotting and qPCR. VEGFA expression is elevated in multiple tumour types and correlates with the prognosis of tumour patients. VEGFA is involved in regulating the tumour microenvironment and immune cell function in tumour development. Inhibition of VEGFA reduces proliferation, invasion, and migration and promotes apoptosis in HCC cells. VEGFA is a potential predictive biomarker for the diagnosis and prognosis of HCC.
Funder
China Postdoctoral Science Foundation
Huxiang Youth Talent Support Program
Subject
Cell Biology,Molecular Medicine
Cited by
1 articles.
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