Spike protein of SARS‐CoV‐2 Omicron (B.1.1.529) variant has a reduced ability to induce the immune response-Reference-Cited by-同舟云学术

Spike protein of SARS‐CoV‐2 Omicron (B.1.1.529) variant has a reduced ability to induce the immune response

Published:2022-04-09 Issue:1 Volume:7 Page:
ISSN:2059-3635
Container-title:Signal Transduction and Targeted Therapy
language:en
Short-container-title:Sig Transduct Target Ther

Author:

He Cai,He Xuemei,Yang Jingyun,Lei Hong,Hong Weiqi^ORCID,Song Xiangrong^ORCID,Yang Li,Li Jiong,Wang Wei^ORCID,Shen Guobo,Lu Guangwen^ORCID,Wei Xiawei^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics

Link

https://www.nature.com/articles/s41392-022-00980-6.pdf

Reference6 articles.

1. Cao, Y. et al. Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies. Nature 602, 657–663 (2022).

2. Yang, J. et al. A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity. Nature 586, 572–577 (2020).

3. Lederer, K. et al. SARS-CoV-2 mRNA vaccines foster potent antigen-specific germinal center responses associated with neutralizing antibody generation. Immunity 53, 1281–1295 e1285 (2020).

4. Lin, S. et al. Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD-binding. Signal Transduct. Target. Ther 7, 56 (2022).

5. Servellita, V. et al. Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants. Cell https://doi.org/10.1016/j.cell.2022.03.019 (2022).

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