Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding-Reference-Cited by-同舟云学术

Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding

Published:2022-02-21 Issue:1 Volume:7 Page:
ISSN:2059-3635
Container-title:Signal Transduction and Targeted Therapy
language:en
Short-container-title:Sig Transduct Target Ther

Author:

Lin Sheng,Chen Zimin,Zhang Xindan,Wen Ao,Yuan Xin,Yu Chongzhang,Yang Jing,He Bin,Cao Yu,Lu Guangwen^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics

Link

https://www.nature.com/articles/s41392-022-00914-2.pdf

Reference5 articles.

1. World Health Organization. Update 72-SARS-CoV-2 Variant of Concern Omicron. https://www.who.int/teams/risk-communication/epi-win-updates (World Health Organization, 2022).

2. Yuan, M. et al. Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants. Science 373, 818–823 (2021).

3. Ye, F. et al. S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis. Signal Transduct. Target Ther. 6, 343 (2021).

4. Khan, A. et al. A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Crit. Care 21, 234 (2017).

5. Xiao, F. et al. Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology 158, 1831–1833 (2020).

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