Surveilling microglia dampens neuronal activity: operation of a purinergically mediated negative feedback mechanism
Author:
Funder
Project First-Class Disciplines Development of Chengdu University of TCM
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics
Link
http://www.nature.com/articles/s41392-021-00586-4.pdf
Reference5 articles.
1. Badimon, A. et al. Negative feedback control of neuronal activity by microglia. Nature 586, 417–423 (2020).
2. Illes, P., Rubini, P., Ulrich, H., Zhao, Y. & Tang, Y. Regulation of microglial functions by purinergic mechanisms in the healthy and diseased CNS. Cells 9, 1108 (2020).
3. Nimmerjahn, A., Kirchhoff, F. & Helmchen, F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314–1318 (2005).
4. Eyo, U. B. et al. Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus. J. Neurosci. 34, 10528–10540 (2014).
5. Cserep, C. et al. Microglia monitor and protect neuronal function through specialized somatic purinergic junctions. Science 367, 528–537 (2020).
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