Microglia monitor and protect neuronal function through specialized somatic purinergic junctions-Reference-Cited by-同舟云学术

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

Published:2020-01-31 Issue:6477 Volume:367 Page:528-537
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cserép Csaba¹^ORCID,Pósfai Balázs¹²^ORCID,Lénárt Nikolett¹^ORCID,Fekete Rebeka¹²^ORCID,László Zsófia I.²³^ORCID,Lele Zsolt³^ORCID,Orsolits Barbara¹^ORCID,Molnár Gábor⁴^ORCID,Heindl Steffanie⁵^ORCID,Schwarcz Anett D.¹,Ujvári Katinka¹,Környei Zsuzsanna¹^ORCID,Tóth Krisztina¹²^ORCID,Szabadits Eszter¹,Sperlágh Beáta⁶^ORCID,Baranyi Mária⁶,Csiba László⁷,Hortobágyi Tibor⁸⁹¹⁰^ORCID,Maglóczky Zsófia¹¹,Martinecz Bernadett¹^ORCID,Szabó Gábor¹²^ORCID,Erdélyi Ferenc¹²^ORCID,Szipőcs Róbert¹³^ORCID,Tamkun Michael M.¹⁴^ORCID,Gesierich Benno⁵,Duering Marco⁵¹⁵^ORCID,Katona István³^ORCID,Liesz Arthur⁵¹⁵^ORCID,Tamás Gábor⁴^ORCID,Dénes Ádám¹^ORCID

Affiliation:

1. Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.

2. Szentágothai János Doctoral School of Neuroscience, Semmelweis University, Budapest, Hungary.

3. Momentum Laboratory of Molecular Neurobiology, Institute of Experimental Medicine, Budapest, Hungary.

4. MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.

5. Institute for Stroke and Dementia Research, Ludwig-Maximilians-University, Munich, Germany.

6. Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Budapest, Hungary.

7. MTA-DE Cerebrovascular and Neurodegenerative Research Group, Department of Neurology, University of Debrecen, Debrecen, Hungary.

8. Institute of Pathology, Faculty of Medicine, University of Szeged, Szeged, Hungary.

9. Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK.

10. Centre for Age-Related Medicine, SESAM, Stavanger University Hospital, Stavanger, Norway.

11. Human Brain Research Laboratory, Institute of Experimental Medicine, Budapest, Hungary.

12. Medical Gene Technology Unit, Institute of Experimental Medicine, Budapest, Hungary.

13. Institute for Solid State Physics and Optics of Wigner RCP, Budapest, Hungary.

14. Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.

15. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

Abstract

Microglia take control Changes in the activity of microglia, the primary immune cells of the central nervous system, are linked with major human diseases, including stroke, epilepsy, psychiatric disorders, and neurodegeneration. Cserép et al. identified a specialized morphofunctional communication site between microglial processes and neuronal cell bodies in the mouse and the human brain (see the Perspective by Nimmerjahn). These junctions are formed at specific areas of the neuronal somatic membranes and possess a distinctive nanoarchitecture and specialized molecular composition linked to mitochondrial signaling. The junctions appear to provide a major site for microglia-neuron communication and may help to mediate the neuroprotective effects of microglia after acute brain injury. Science , this issue p. 528 ; see also p. 510

Funder

National Institutes of Health

European Commission

European Research Council

Hungarian Academy of Sciences

Hungarian National Brain Research Program

Hungarian Scientific Research Fund

National Research, Development and Innovation Office of Hungary

Ministry of Human Capacities, Hungary

German Research Foundation

Munich Cluster for Systems Neurology

Ministry for Innovation and Technology