Structural insight into allosteric modulation of protease-activated receptor 2-Reference-Cited by-同舟云学术

Structural insight into allosteric modulation of protease-activated receptor 2

Published:2017-04-26 Issue:7652 Volume:545 Page:112-115
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Cheng Robert K. Y.,Fiez-Vandal Cédric,Schlenker Oliver,Edman Karl,Aggeler Birte,Brown Dean G.,Brown Giles A.,Cooke Robert M.,Dumelin Christoph E.,Doré Andrew S.,Geschwindner Stefan,Grebner Christoph,Hermansson Nils-Olov,Jazayeri Ali,Johansson Patrik,Leong Louis,Prihandoko Rudi,Rappas Mathieu,Soutter Holly,Snijder Arjan,Sundström Linda,Tehan Benjamin,Thornton Peter,Troast Dawn,Wiggin Giselle,Zhukov Andrei,Marshall Fiona H.,Dekker Niek

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature22309.pdf

Reference28 articles.

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2. Nystedt, S., Emilsson, K., Larsson, A. K., Strömbeck, B. & Sundelin, J. Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. Eur. J. Biochem. 232, 84–89 (1995)

3. Ramachandran, R., Noorbakhsh, F., Defea, K. & Hollenberg, M. D. Targeting proteinase-activated receptors: therapeutic potential and challenges. Nat. Rev. Drug Discov. 11, 69–86 (2012)

4. Chackalamannil, S. et al. Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity. J. Med. Chem. 51, 3061–3064 (2008)

5. Zhang, C. et al. High-resolution crystal structure of human protease-activated receptor 1. Nature 492, 387–392 (2012)

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