Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity

Author:

Chackalamannil Samuel1,Wang Yuguang1,Greenlee William J.1,Hu Zhiyong1,Xia Yan1,Ahn Ho-Sam1,Boykow George1,Hsieh Yunsheng1,Palamanda Jairam1,Agans-Fantuzzi Jacqueline1,Kurowski Stan1,Graziano Michael1,Chintala Madhu1

Affiliation:

1. Schering-Plough Research Institute, 2015 Galloping Hill Rd, Kenilworth, New Jersey 07033

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference36 articles.

1. World Health Organization. Atlas of Heart Disease and Stroke;World Health Organization:Geneva, Switzerland, 2004.

2. National Center for Health Statistics. Health, United States, 2005 with Chartbook on Trends in the Health of Americans;National Center for Health Statistics:Hyattsville, MD, 2005, p178.

3. Inflammation, Atherosclerosis, and Coronary Artery Disease

4. Macrophage Activation in Atherosclerosis: Pathogenesis and Pharmacology of Plaque Rupture

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