A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo

Author:

Cooper Nicola,Teixeira Mauro M,Warneck Julie,Miotla Jadwiga M,Wills Ruth E,Macari David M T,Gristwood Robert W,Hellewell Paul G

Publisher

Wiley

Subject

Pharmacology

Reference40 articles.

1. Effect of PDE4 inhibitors on zymosan-induced IL-8 release form human neutrophils: Synergism with prostanoids and salbutamol;AU;Br. J. Pharmacol.,1998

2. Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: correlation between function and interaction with a high-affinity rolipram binding site;BARNETTE;J. Pharmacol. Exp. Ther.,1995a

3. The ability of phosphodiesterase IV inhibitors to suppress superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity;BARNETTE;J. Pharmacol. Exp. Ther.,1995b

4. Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipram binding;BARNETTE;Biochem. Pharmacol.,1996

5. SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions;BARNETTE;J. Pharmacol. Exp. Ther.,1998

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