Design and synthesis of 4,5,6,7‐tetrahydro‐1 H ‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors-Reference-Cited by-同舟云学术

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Design and synthesis of 4,5,6,7‐tetrahydro‐1 H ‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors

Published:2017-01 Issue:1 Volume:27 Page:24-29
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Guariento Sara,Karawajczyk Anna,Bull James A.,Marchini Gessica,Bielska Martyna,Iwanowa Xenia,Bruno Olga,Fossa Paola,Giordanetto Fabrizio

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference44 articles.

1. Cyclic AMP-specific PDE4 Phosphodiesterases as Critical Components of Cyclic AMP Signaling

2. cAMP-Specific Phosphodiesterase-4 Enzymes in the Cardiovascular System

3. PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

4. The Protein Data Bank

5. Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

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4. The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure;European Journal of Medicinal Chemistry;2021-02

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