Abstract
AbstractPrimary neurulation is the process by which the neural tube, the central nervous system precursor, is formed from the neural plate. Incomplete neural tube closure occurs frequently, yet underlying causes remain poorly understood. Developmental studies in amniotes and amphibians have identified hingepoint and neural fold formation as key morphogenetic events and hallmarks of primary neurulation, the disruption of which causes neural tube defects. In contrast, the mode of neurulation in teleosts has remained highly debated. Teleosts are thought to have evolved a unique mode of neurulation, whereby the neural plate infolds in absence of hingepoints and neural folds, at least in the hindbrain/trunk where it has been studied. Using high-resolution imaging and time-lapse microscopy, we show here the presence of these morphological landmarks in the zebrafish anterior neural plate. These results reveal similarities between neurulation in teleosts and other vertebrates and hence the suitability of zebrafish to understand human neurulation.
Funder
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences
National Science Foundation
Howard Hughes Medical Institute
Publisher
Springer Science and Business Media LLC
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference64 articles.
1. Copp, A. J., Greene, N. D. E. & Murdoch, J. N. Dishevelled: linking convergent extension with neural tube closure. Trends Neurosci. 26, 453–455 (2003).
2. Keller, R. Shaping the vertebrate body plan by polarized embryonic cell movements. Science 298, 1950–1954 (2002).
3. Copp, A. J., Greene, N. D. E. & Murdoch, J. N. The genetic basis of mammalian neurulation. Nat. Rev. Genet. 4, 784–793 (2003).
4. Morriss-Kay, G. M. Growth and development of pattern in the cranial neural epithelium of rat embryos during neurulation. J. Embryol. Exp. Morphol. 65, 225–241 (1981). Suppl.
5. Baker, P. C. & Schroeder, T. E. Cytoplasmic filaments and morphogenetic movement in the amphibian neural tube. Dev. Biol. 15, 432–450 (1967).
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