BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation-Reference-Cited by-同舟云学术

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

Published:2017-11-08 Issue:7680 Volume:551 Page:384-388
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Raffel Simon,Falcone Mattia,Kneisel Niclas,Hansson Jenny,Wang Wei,Lutz Christoph,Bullinger Lars,Poschet Gernot,Nonnenmacher Yannic,Barnert Andrea,Bahr Carsten,Zeisberger Petra,Przybylla Adriana,Sohn Markus,Tönjes Martje,Erez Ayelet,Adler Lital,Jensen Patrizia,Scholl Claudia,Fröhling Stefan,Cocciardi Sibylle,Wuchter Patrick,Thiede Christian,Flörcken Anne,Westermann Jörg,Ehninger Gerhard,Lichter Peter,Hiller Karsten,Hell Rüdiger,Herrmann Carl,Ho Anthony D.,Krijgsveld Jeroen,Radlwimmer Bernhard,Trumpp Andreas

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature24294.pdf

Reference40 articles.

1. Tönjes, M. et al. BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1. Nat. Med. 19, 901–908 (2013)

2. Wang, Z. Q. et al. BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism. Oncotarget 6, 31522–31543 (2015)

3. Zheng, Y. H. et al. BCAT1, a key prognostic predictor of hepatocellular carcinoma, promotes cell proliferation and induces chemoresistance to cisplatin. Liver Int. 36, 1836–1847 (2016)

4. Thewes, V. et al. The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer. Oncogene 36, 4124–4134 (2017)

5. Mayers, J. R. et al. Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science 353, 1161–1165 (2016)

Cited by 271 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Fueling the fight against cancer: Exploring the impact of branched-chain amino acid catalyzation on cancer and cancer immune microenvironment;Metabolism;2024-12

2. Epigenetic modifications in hematopoietic ecosystem: a key tuner from homeostasis to acute myeloid leukemia;Blood Science;2024-09-12

3. Interplay between epigenetics and metabolism controls cancer stem cell plasticity;Frontiers in Epigenetics and Epigenomics;2024-09-11

4. Identify BCAT1 plays an oncogenic role and promotes EMT in KIRC via single cell RNA-seq and experiment;Frontiers in Oncology;2024-09-11

5. The Role of DNMT Methyltransferases and TET Dioxygenases in the Maintenance of the DNA Methylation Level;Biomolecules;2024-09-04