Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice-Reference-Cited by-同舟云学术

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Published:2015-09-23 Issue:1 Volume:6 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Deprez-Poulain Rebecca,Hennuyer Nathalie,Bosc Damien,Liang Wenguang G.,Enée Emmanuelle,Marechal Xavier,Charton Julie,Totobenazara Jane,Berte Gonzague,Jahklal Jouda,Verdelet Tristan,Dumont Julie,Dassonneville Sandrine,Woitrain Eloise,Gauriot Marion,Paquet Charlotte,Duplan Isabelle,Hermant Paul,Cantrelle François- Xavier,Sevin Emmanuel,Culot Maxime,Landry Valerie,Herledan Adrien,Piveteau Catherine,Lippens Guy,Leroux Florence,Tang Wei-Jen,van Endert Peter,Staels Bart,Deprez Benoit

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms9250.pdf

Reference45 articles.

1. Fernandez-Gamba, A., Leal, M. C., Morelli, L. & Castano, E. M. Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease. Curr. Pharm. Des. 15, 3644–3655 (2009) .

2. Hersh, L. B. The insulysin (insulin degrading enzyme) enigma. Cell. Mol. Life Sci. 63, 2432–2434 (2006) .

3. Kurochkin, I. V. & Goto, S. Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett. 345, 33–37 (1994) .

4. Guo, Q., Manolopoulou, M., Bian, Y., Schilling, A. B. & Tang, W.-J. Molecular basis for the recognition and cleavages of IGF-II, TGF-[alpha], and amylin by human insulin-degrading enzyme. J. Mol. Biol. 395, 430–443 (2010) .

5. Authier, F., Cameron, P. H., Merlen, C., Kouach, M. & Briand, G. Endosomal proteolysis of glucagon at neutral pH generates the bioactive degradation product miniglucagon-(19-29). Endocrinology 144, 5353–5364 (2003) .

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