Paradoxical activation of MEK/ERK signaling induced by B-Raf inhibition enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells-Reference-Cited by-同舟云学术

Paradoxical activation of MEK/ERK signaling induced by B-Raf inhibition enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells

Published:2016-05-25 Issue:1 Volume:6 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Oh You-Take,Deng Jiusheng,Yue Ping,Sun Shi-Yong

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep26803.pdf

Reference40 articles.

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3. Li, H. F. et al. Recent advances in the research and development of B-Raf inhibitors. Curr Med Chem 17, 1618–1634 (2010).

4. Rheault, T. R. et al. Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors. ACS medicinal chemistry letters 4, 358–362 (2013).

5. Akinleye, A., Furqan, M., Mukhi, N., Ravella, P. & Liu, D. MEK and the inhibitors: from bench to bedside. J Hematol Oncol 6, 27 (2013).

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