Vemurafenib Inhibits Acute and Chronic Enterovirus Infection by Affecting Cellular Kinase Phosphatidylinositol 4-Kinase Type IIIβ-Reference-Cited by-同舟云学术

Vemurafenib Inhibits Acute and Chronic Enterovirus Infection by Affecting Cellular Kinase Phosphatidylinositol 4-Kinase Type IIIβ

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Laajala Mira¹,Zwaagstra Marleen²,Martikainen Mari¹,Nekoua Magloire Pandoua³,Benkahla Mehdi³,Sane Famara³,Gervais Emily⁴,Campagnola Grace⁴,Honkimaa Anni⁵,Sioofy-Khojine Amir-Babak⁵,Hyöty Heikki⁵⁶,Ojha Ravi⁷^ORCID,Bailliot Marie⁷,Balistreri Giuseppe⁷⁸^ORCID,Peersen Olve⁴^ORCID,Hober Didier³,Van Kuppeveld Frank²,Marjomäki Varpu¹^ORCID

Affiliation:

1. Department of Biological and Environmental Science/Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland

2. Section of Virology, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands

3. Laboratoire de Virologie ULR3610, Université de Lille, CHU Lille, Lille, France

4. Department of Biochemistry & Molecular Biology, Colorado State University, Fort Collins, Colorado, USA

5. Department of Virology, Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland

6. Fimlab Laboratories, Tampere, Finland

7. Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland

8. Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia

Abstract

Despite the prevalence and medical threat of enteroviruses, presently, there are no antivirals against them. Here, we show that vemurafenib, an FDA-approved RAF kinase inhibitor for treating BRAF V600E mutant-related melanoma, prevents enterovirus translation and replication.

Funder

Academy of Finland

Business Finland

HHS | National Institutes of Health

Jane ja Aatos Erkon Säätiö

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00552-23

Reference69 articles.

1. Picornavirus and enterovirus diversity with associated human diseases

2. Role of enteroviruses in the pathogenesis of type 1 diabetes

3. Coxsackievirus B1 Is Associated With Induction of β-Cell Autoimmunity That Portends Type 1 Diabetes

4. Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus

5. Enterovirus 71 infection and vaccines