Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/s41589-019-0279-5.pdf
Reference51 articles.
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2. Lebraud, H. & Heightman, T. D. Protein degradation: a validated therapeutic strategy with exciting prospects. Essays Biochem. 61, 517–527 (2017).
3. Bondeson, D. P. & Crews, C. M. Targeted protein degradation by small molecules. Annu. Rev. Pharmacol. Toxicol. 57, 107–123 (2017).
4. Collins, I., Wang, H., Caldwell, J. J. & Chopra, R. Chemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathway. Biochem. J. 474, 1127–1147 (2017).
5. Hughes, S. J. & Ciulli, A. Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders. Essays Biochem. 61, 505–516 (2017).
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