Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
https://www.nature.com/articles/s41589-022-01015-5.pdf
Reference60 articles.
1. Bettica, P. et al. Histological effects of givinostat in boys with Duchenne muscular dystrophy. Neuromuscul. Disord. 26, 643–649 (2016).
2. Li, Y. & Seto, E. HDACs and HDAC inhibitors in cancer development and therapy. Cold Spring Harb. Perspect. Med. 6, a026831 (2016).
3. Saito, M. et al. Acetylation of intrinsically disordered regions regulates phase separation. Nat. Chem. Biol. 15, 51–61 (2019).
4. Federspiel, J. D., Greco, T. M., Lum, K. K. & Cristea, I. M. Hdac4 interactions in Huntington’s disease viewed through the prism of multiomics. Mol. Cell. Proteomics 18, S92–S113 (2019).
5. Bardai, F. H. & D’Mello, S. R. Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3β. J. Neurosci. 31, 1746–1751 (2011).
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