Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
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Published:2016-08-08
Issue:9
Volume:48
Page:1055-1059
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ISSN:1061-4036
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Container-title:Nature Genetics
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language:en
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Short-container-title:Nat Genet
Author:
Zhou KaixinORCID, , Yee Sook Wah, Seiser Eric L, van Leeuwen Nienke, Tavendale Roger, Bennett Amanda J, Groves Christopher J, Coleman Ruth L, van der Heijden Amber A, Beulens Joline W, de Keyser Catherine E, Zaharenko Linda, Rotroff Daniel M, Out Mattijs, Jablonski Kathleen A, Chen Ling, Javorský Martin, Židzik Jozef, Levin Albert M, Williams L Keoki, Dujic Tanja, Semiz SabinaORCID, Kubo Michiaki, Chien Huan-Chieh, Maeda Shiro, Witte John S, Wu Longyang, Tkáč Ivan, Kooy Adriaan, van Schaik Ron H N, Stehouwer Coen D A, Logie Lisa, Sutherland Calum, Klovins Janis, Pirags Valdis, Hofman Albert, Stricker Bruno H, Motsinger-Reif Alison A, Wagner Michael J, Innocenti Federico, Hart Leen M 't, Holman Rury R, McCarthy Mark I, Hedderson Monique M, Palmer Colin N A, Florez Jose C, Giacomini Kathleen M, Pearson Ewan R, ,
Publisher
Springer Science and Business Media LLC
Reference51 articles.
1. Madiraju, A.K. et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature 510, 542–546 (2014). 2. DeFronzo, R.A. & Goodman, A.M. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 333, 541–549 (1995). 3. UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352, 854–865 (1998). 4. Zhou, K. et al. Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis. Lancet Diabetes Endocrinol. 2, 481–487 (2014). 5. Pawlyk, A.C., Giacomini, K.M., McKeon, C., Shuldiner, A.R. & Florez, J.C. Metformin pharmacogenomics: current status and future directions. Diabetes 63, 2590–2599 (2014).
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