Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase-Reference-Cited by-同舟云学术

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Published:2014-05-21 Issue:7506 Volume:510 Page:542-546
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Madiraju Anila K.,Erion Derek M.,Rahimi Yasmeen,Zhang Xian-Man,Braddock Demetrios T.,Albright Ronald A.,Prigaro Brett J.,Wood John L.,Bhanot Sanjay,MacDonald Michael J.,Jurczak Michael J.,Camporez Joao-Paulo,Lee Hui-Young,Cline Gary W.,Samuel Varman T.,Kibbey Richard G.,Shulman Gerald I.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature13270.pdf

Reference33 articles.

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2. Inzucchi, S. et al. Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus. N. Engl. J. Med. 338, 867–872 (1998)

3. El-Mir, M.-Y. et al. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J. Biol. Chem. 275, 223–228 (2000)

4. Owen, M. R., Doran, E. & Halestrap, A. P. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem. J. 348, 607–614 (2000)

5. Zhou, G. et al. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108, 1167–1174 (2001)

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