A coiled-coil masking domain for selective activation of therapeutic antibodies
Author:
Publisher
Springer Science and Business Media LLC
Subject
Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
http://www.nature.com/articles/s41587-019-0135-x.pdf
Reference33 articles.
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3. Polu, K. R. & Lowman, H. B. Probody therapeutics for targeting antibodies to diseased tissue. Expert Opin. Biol. Ther. 14, 1049–1053 (2014).
4. Desnoyers, L. R. et al. Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index. Sci. Transl. Med. 5, 207ra144 (2013).
5. Donaldson, J., Kari, C., Fragoso, R., Rodeck, U. & Williams, J. C. Design and development of masked therapeutic antibodies to limit off-target effects: application to anti-EGFR antibodies. Cancer Biol. Ther. 8, 2147–2152 (2009).
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