A coiled-coil masking domain for selective activation of therapeutic antibodies-Reference-Cited by-同舟云学术

A coiled-coil masking domain for selective activation of therapeutic antibodies

Published:2019-05-27 Issue:7 Volume:37 Page:761-765
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Trang Vivian H.,Zhang Xinqun,Yumul Roma C.,Zeng Weiping,Stone Ivan J.,Wo Serena W.,Dominguez Melissa M.,Cochran Julia H.,Simmons Jessica K.,Ryan Maureen C.,Lyon Robert P.,Senter Peter D.,Levengood Matthew R.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/s41587-019-0135-x.pdf

Reference33 articles.

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3. Polu, K. R. & Lowman, H. B. Probody therapeutics for targeting antibodies to diseased tissue. Expert Opin. Biol. Ther. 14, 1049–1053 (2014).

4. Desnoyers, L. R. et al. Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index. Sci. Transl. Med. 5, 207ra144 (2013).

5. Donaldson, J., Kari, C., Fragoso, R., Rodeck, U. & Williams, J. C. Design and development of masked therapeutic antibodies to limit off-target effects: application to anti-EGFR antibodies. Cancer Biol. Ther. 8, 2147–2152 (2009).

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