CRISPR-free, strand-selective mitochondrial DNA base editing using a nickase
Author:
Publisher
Springer Science and Business Media LLC
Subject
Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
https://www.nature.com/articles/s41587-023-01820-w.pdf
Reference5 articles.
1. Gammage, P. A., Moraes, C. T. & Minczuk, M. Mitochondrial genome engineering: the revolution may not be CRISPR-ized. Trends Genet. 34, 101–110 (2018). This review article presents the challenges of transporting RNAs into mitochondria.
2. Mok, B. Y. et al. A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing. Nature 583, 631–637 (2020). This paper describes the mtDNA cytosine DdCBE base editors.
3. Cho, S. I. et al. Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases. Cell 185, 1764–1776 (2022). This paper describes the TALED mtDNA adenine base editors.
4. Lei, Z. et al. Mitochondrial base editor induces substantial nuclear off-target mutations. Nature 606, 804–811 (2022). This paper reports the off-target risks of DdCBEs.
5. Vafai, S. B. & Mootha, V. K. Mitochondrial disorders as windows into an ancient organelle. Nature 491, 374–383 (2012). This review article describes how mtDNA mutations are associated with a range of human diseases.
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