Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases
Author:
Funder
Institute for Basic Science
Publisher
Elsevier BV
Subject
General Biochemistry, Genetics and Molecular Biology
Reference36 articles.
1. MitoTALEN reduces mutant mtDNA load and restores tRNA(Ala) levels in a mouse model of heteroplasmic mtDNA mutation;Bacman;Nat. Med.,2018
2. Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations;Gammage;EMBO Mol. Med.,2014
3. Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs;Gammage;Nucleic Acids Res.,2016
4. Mitochondrial genome engineering: the revolution may not be CRISPR-Ized;Gammage;Trends Genet.,2018
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