A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing-Reference-Cited by-同舟云学术

A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing

Published:2020-06-01 Issue:7 Volume:38 Page:861-864
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Grünewald Julian^ORCID,Zhou Ronghao^ORCID,Lareau Caleb A.^ORCID,Garcia Sara P.^ORCID,Iyer Sowmya,Miller Bret R.^ORCID,Langner Lukas M.^ORCID,Hsu Jonathan Y.,Aryee Martin J.^ORCID,Joung J. Keith^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/s41587-020-0535-y.pdf

Reference24 articles.

1. Komor, A. C., Kim, Y. B., Packer, M. S., Zuris, J. A. & Liu, D. R. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature 533, 420–424 (2016).

2. Gaudelli, N. M. et al. Programmable base editing of A*T to G*C in genomic DNA without DNA cleavage. Nature 551, 464–471 (2017).

3. Komor, A. C. et al. Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity. Sci. Adv. 3, eaao4774 (2017).

4. Rees, H. A. & Liu, D. R. Base editing: precision chemistry on the genome and transcriptome of living cells. Nat. Rev. Genet. 19, 770–788 (2018).

5. Nishida, K. et al. Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems. Science 353, aaf8729 (2016).

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