Implications of endogenous roles of transporters for drug discovery: hitchhiking and metabolite-likeness
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd.2015.44.pdf
Reference10 articles.
1. Nigam, S. K. What do drug transporters really do? Nat. Rev. Drug Discov. 14, 29–44 (2015).
2. César-Razquin, A. et al. A call for systematic research on solute carriers. Cell 162, 478–487 (2015).
3. Dobson, P. D. & Kell, D. B. Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? Nat. Rev. Drug Discov. 7, 205–220 (2008).
4. Kell, D. B. & Oliver, S. G. How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion. Front. Pharmacol. 5, 231 (2014).
5. Winter, G. E. et al. The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity. Nat. Chem. Biol. 10, 768–773 (2014).
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