Genetic gear switches drive cancer immune evasion
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Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41588-024-01778-8.pdf
Reference5 articles.
1. Germano, G., Amirouchene-Angelozzi, N., Rospo, G. & Bardelli, A. The clinical impact of the genomic landscape of mismatch repair-deficient cancers. Cancer Discov 8, 1518–1528 (2018). This review article discusses the clonal evolution of hypermutator cancers in a clinical context.
2. Rosenberg, S. M., Longerich, S., Gee, P. & Harris, R. S. Adaptive mutation by deletions in small mononucleotide repeats. Science 265, 405–407 (1994). This seminal paper revealed evidence for adaptive homopolymer frameshift switching in bacteria.
3. Zou, X. et al. A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage. Nat. Cancer 2, 643–657 (2021). This study used elegant CRISPR-knockout models to define mutation signatures associated with MMR loss.
4. Fang, H. et al. Deficiency of replication-independent DNA mismatch repair drives a 5-methylcytosine deamination mutational signature in cancer. Sci. Adv. 7, eabg4398 (2021). This study used bulk sample analyses to deconvolute MMR mutation signatures, and revealed replication-independent functions of MMR in safeguarding genomic integrity.
5. Sanders, M. A. et al. Life without mismatch repair. Preprint at bioRxiv https://doi.org/10.1101/2021.04.14.437578 (2021). This preprint studies patients with constitutional MMRd to measure mutation rates associated with loss of MMR in vivo.
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