Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
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Published:2023-11-09
Issue:12
Volume:55
Page:2065-2074
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ISSN:1061-4036
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Container-title:Nature Genetics
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language:en
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Short-container-title:Nat Genet
Author:
Wang AnqiORCID, Shen JiayiORCID, Rodriguez Alex A., Saunders Edward J., Chen Fei, Janivara RohiniORCID, Darst Burcu F.ORCID, Sheng Xin, Xu YiliORCID, Chou Alisha J.ORCID, Benlloch Sara, Dadaev TokhirORCID, Brook Mark N.ORCID, Plym Anna, Sahimi Ali, Hoffman Thomas J.ORCID, Takahashi AtushiORCID, Matsuda KoichiORCID, Momozawa YukihideORCID, Fujita MasashiORCID, Laisk TriinORCID, Figuerêdo Jéssica, Muir KennethORCID, Ito Shuji, Liu Xiaoxi, Yamanashi Yuji, Furukawa Yoichi, Morisaki Takayuki, Murakami Yoshinori, Muto Kaori, Nagai Akiko, Obara Wataru, Yamaji Ken, Takahashi Kazuhisa, Asai Satoshi, Takahashi Yasuo, Suzuki Takao, Sinozaki Nobuaki, Yamaguchi Hiroki, Minami Shiro, Murayama Shigeo, Yoshimori Kozo, Nagayama Satoshi, Obata Daisuke, Higashiyama Masahiko, Masumoto Akihide, Koretsune Yukihiro, Uchio YujiORCID, Kubo Michiaki, Kamatani YoichiroORCID, Lophatananon Artitaya, Wan Peggy, Andrews Caroline, Lori Adriana, Choudhury Parichoy P., Schleutker JohannaORCID, Tammela Teuvo L. J., Sipeky CsillaORCID, Auvinen AnssiORCID, Giles Graham G.ORCID, Southey Melissa C.ORCID, MacInnis Robert J., Cybulski Cezary, Wokolorczyk Dominika, Lubinski Jan, Rentsch Christopher T.ORCID, Cho Kelly, Mcmahon Benjamin H., Neal David E., Donovan Jenny L., Hamdy Freddie C., Martin Richard M.ORCID, Nordestgaard Borge G.ORCID, Nielsen Sune F., Weischer Maren, Bojesen Stig E.ORCID, Røder AndreasORCID, Stroomberg Hein V.ORCID, Batra JyotsnaORCID, Chambers Suzanne, Horvath LisaORCID, Clements Judith A.ORCID, Tilly WayneORCID, Risbridger Gail P.ORCID, Gronberg HenrikORCID, Aly MarkusORCID, Szulkin Robert, Eklund MartinORCID, Nordstrom TobiasORCID, Pashayan NoraORCID, Dunning Alison M.ORCID, Ghoussaini MayaORCID, Travis Ruth C.ORCID, Key Tim J., Riboli ElioORCID, Park Jong Y.ORCID, Sellers Thomas A., Lin Hui-Yi, Albanes DemetriusORCID, Weinstein StephanieORCID, Cook Michael B., Mucci Lorelei A., Giovannucci Edward, Lindstrom Sara, Kraft PeterORCID, Hunter David J., Penney Kathryn L., Turman Constance, Tangen Catherine M., Goodman Phyllis J., Thompson Ian M., Hamilton Robert J., Fleshner Neil E., Finelli Antonio, Parent Marie-ÉliseORCID, Stanford Janet L., Ostrander Elaine A.ORCID, Koutros Stella, Beane Freeman Laura E., Stampfer Meir, Wolk AlicjaORCID, Håkansson NiclasORCID, Andriole Gerald L., Hoover Robert N., Machiela Mitchell J.ORCID, Sørensen Karina DalsgaardORCID, Borre Michael, Blot William J., Zheng WeiORCID, Yeboah Edward D., Mensah James E.ORCID, Lu Yong-JieORCID, Zhang Hong-Wei, Feng Ninghan, Mao Xueying, Wu Yudong, Zhao Shan-ChaoORCID, Sun Zan, Thibodeau Stephen N., McDonnell Shannon K., Schaid Daniel J., West Catharine M. L.ORCID, Barnett Gill, Maier Christiane, Schnoeller Thomas, Luedeke Manuel, Kibel Adam S., Drake Bettina F., Cussenot Olivier, Cancel-Tassin GeraldineORCID, Menegaux Florence, Truong ThérèseORCID, Koudou Yves Akoli, John Esther M., Grindedal Eli Marie, Maehle Lovise, Khaw Kay-Tee, Ingles Sue A., Stern Mariana C., Vega AnaORCID, Gómez-Caamaño AntonioORCID, Fachal Laura, Rosenstein Barry S., Kerns Sarah L., Ostrer Harry, Teixeira Manuel R.ORCID, Paulo Paula, Brandão AndreiaORCID, Watya Stephen, Lubwama Alexander, Bensen Jeannette T., Butler Ebonee N., Mohler James L.ORCID, Taylor Jack A.ORCID, Kogevinas Manolis, Dierssen-Sotos Trinidad, Castaño-Vinyals GemmaORCID, Cannon-Albright LisaORCID, Teerlink Craig C., Huff Chad D., Pilie Patrick, Yu YaoORCID, Bohlender Ryan J.ORCID, Gu JianORCID, Strom Sara S., Multigner LucORCID, Blanchet Pascal, Brureau Laurent, Kaneva Radka, Slavov Chavdar, Mitev Vanio, Leach Robin J., Brenner HermannORCID, Chen Xuechen, Holleczek Bernd, Schöttker Ben, Klein Eric A.ORCID, Hsing Ann W., Kittles Rick A., Murphy Adam B.ORCID, Logothetis Christopher J.ORCID, Kim Jeri, Neuhausen Susan L.ORCID, Steele Linda, Ding Yuan Chun, Isaacs William B., Nemesure Barbara, Hennis Anselm J. M., Carpten John, Pandha Hardev, Michael AgnieszkaORCID, De Ruyck Kim, De Meerleer Gert, Ost PietORCID, Xu JianfengORCID, Razack Azad, Lim Jasmine, Teo Soo-HwangORCID, Newcomb Lisa F., Lin Daniel W., Fowke Jay H., Neslund-Dudas Christine M., Rybicki Benjamin A., Gamulin MarijaORCID, Lessel DavorORCID, Kulis TomislavORCID, Usmani Nawaid, Abraham Aswin, Singhal Sandeep, Parliament Matthew, Claessens Frank, Joniau StevenORCID, Van den Broeck Thomas, Gago-Dominguez Manuela, Castelao Jose Esteban, Martinez Maria Elena, Larkin Samantha, Townsend Paul A., Aukim-Hastie Claire, Bush William S.ORCID, Aldrich Melinda C.ORCID, Crawford Dana C.ORCID, Srivastava Shiv, Cullen Jennifer, Petrovics GyorgyORCID, Casey Graham, Wang YingORCID, Tettey Yao, Lachance JosephORCID, Tang WeiORCID, Biritwum Richard B., Adjei Andrew A., Tay Evelyn, Truelove Ann, Niwa Shelley, Yamoah KosjORCID, Govindasami Koveela, Chokkalingam Anand P., Keaton Jacob M., Hellwege Jacklyn N., Clark Peter E., Jalloh MohamedORCID, Gueye Serigne M., Niang Lamine, Ogunbiyi Olufemi, Shittu Olayiwola, Amodu Olukemi, Adebiyi Akindele O.ORCID, Aisuodionoe-Shadrach Oseremen I., Ajibola Hafees O., Jamda Mustapha A., Oluwole Olabode P., Nwegbu Maxwell, Adusei Ben, Mante SunnyORCID, Darkwa-Abrahams Afua, Diop Halimatou, Gundell Susan M., Roobol Monique J.ORCID, Jenster GuidoORCID, van Schaik Ron H. N., Hu Jennifer J.ORCID, Sanderson Maureen, Kachuri LindaORCID, Varma Rohit, McKean-Cowdin Roberta, Torres Mina, Preuss Michael H.ORCID, Loos Ruth J. F.ORCID, Zawistowski MatthewORCID, Zöllner SebastianORCID, Lu ZeyunORCID, Van Den Eeden Stephen K.ORCID, Easton Douglas F.ORCID, Ambs StefanORCID, Edwards Todd L.ORCID, Mägi ReedikORCID, Rebbeck Timothy R.ORCID, Fritsche LarsORCID, Chanock Stephen J.ORCID, Berndt Sonja I., Wiklund FredrikORCID, Nakagawa HidewakiORCID, Witte John S.ORCID, Gaziano J. Michael, Justice Amy C.ORCID, Mancuso NickORCID, Terao ChikashiORCID, Eeles Rosalind A.ORCID, Kote-Jarai ZsofiaORCID, Madduri Ravi K.ORCID, Conti David V.ORCID, Haiman Christopher A.ORCID,
Funder
U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute Prostate Cancer Foundation
Publisher
Springer Science and Business Media LLC
Reference72 articles.
1. Bray, F. et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394–424 (2018). 2. Conti, D. V. et al. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat. Genet. 53, 65–75 (2021). 3. Schumacher, F. R. et al. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Nat. Genet. 50, 928–936 (2018). 4. Dadaev, T. et al. Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. Nat. Commun. 9, 2256 (2018). 5. Conti, D. V. et al. Two novel susceptibility loci for prostate cancer in men of African ancestry. J. Natl Cancer Inst. 109, djx084 (2017).
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