Abstract
AbstractThe OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13. This haplotype contains a splice variant of OAS1, which occurs in people of African ancestry independently of gene flow from Neanderthals. Using trans-ancestry fine-mapping approaches in 20,779 hospitalized cases, we demonstrate that this splice variant is likely to be the SNP responsible for the association at this locus, thus strongly implicating OAS1 as an effector gene influencing COVID-19 severity.
Funder
Jeanssons Stiftelser
Magnus Bergvalls Stiftelse
NordForsk
Gouvernement du Canada | Instituts de Recherche en Santé du Canada | CIHR Skin Research Training Centre
Fonds de Recherche du Québec-Société et Culture
U.S. Department of Health & Human Services | National Institutes of Health
Japan Society for the Promotion of Science for Young Scientists
U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences
Smilow family
Canadian Foundation for Innovation Genome Québec The Public Health Agency of Canada The McGill Interdisciplinary Initiative in Infection and Immunity
RCUK | Biotechnology and Biological Sciences Research Council
Health Data Research UK
Publisher
Springer Science and Business Media LLC
Cited by
82 articles.
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